The Faculty of Medicine was established in October 1955. The first dean of the Faculty of Medicine was Associate Professor K.A. Zufarov. At that time, the Faculty had 10 departments with 120 students, later the number of students increased and the number of departments also began to increase. By 1957, the head of the Department of Biochemistry, Associate Professor M.G. Mirzakarimov, was appointed as the dean of the Faculty of Medicine. Today, the Faculty offers four specializations: General Medicine, Professional Education, Traditional Medicine, and Higher Nursing. Currently, a total of 5,751 students are studying in these directions, 1,327 on a state grant basis, and 4,424 on a fee-for-service basis. Specifically, in the field of General Medicine, 1,245 students receive state grants, and 3,998 pay tuition fees. For Professional Education direction, 32 students benefit from state grants, whereas 334 pay tuition. Among students of the Traditional Medicine direction, all 49 are paying tuition fees. Lastly, in the direction of Higher Nursing, 14 students enjoy state funding, and another 43 are studying on a fee-based contract basis. In 2023, a sixth-year student Butaboeva Musharrafkhon Makhmudjon kizi became a recipient of the State Scholarship named after Islam Karimov. Other sixth-year students—Shokhjakhon Abdurakhmanov, Dostonbek Alijonov, and Madina Solieva—were awarded the State Scholarships named after Abu Ali ibn Sina.

The Faculty of Pediatrics was established in November 1966. In 1972 the Faculty was closed due to the opening of Central Asian Medical Pediatric Institute in Tashkent and was revived in 1977. To date, there are 14 departments operating within the Faculty of Pediatrics. The faculty trains general pediatric specialists working in the primary health care system. The Faculty employs 238 professors and teachers, of whom 14 are doctors of science (MD), professors, 82 are candidates of science and Associate Professors, 142 are senior lecturers and assistants who teach students the secrets of medical science. Today, 2074 students study at the faculty. Talented students participated in various Republican contests and received scholarships awarded to highly capable students, achieving significant success. For example, sixth-year student Inakova Zebiniso received the Ibn Sina State Scholarship in 2022, while sixth-year student Abdurashidov Abdurauf received the Presidential State Scholarship in 2023. Fifth-year students Azimov Akmal and Tulakov Elbek were granted the Ibn Sina State Scholarship, and Kuldasheva Gulshoda received the Islam Karimov State Scholarship.

The Faculty of Dentistry was established at Andijan State Medical Institute in accordance with the Resolution of the President of the Republic of Uzbekistan No. PQ-2659 issued on November 21, 2016, the Order No.500 dated November 22, 2016 issued by the Ministry of Health, and the Order No.481 dated November 23, 2016 issued by the Ministry of Higher and Secondary Specialized Education. The Faculty began its activities in December 2016. Currently, the faculty is led by a Dean, three Deputy Deans, a Methodologist of the Dean's Office, a Dispatcher for Educational Affairs, and two Secretaries of the Dean's Office. There are currently 14 departments under the faculty’s jurisdiction, located mainly in the institute's educational building, the Institute’s clinic, the Regional Children's Dental Polyclinic and the Regional Dental Clinics. A total of 218 professors and teachers provide education, including 14 doctors of science (MD) and professors, 24 candidates of sciences and Associate Professors, 28 senior lecturers, and 152 assistants and teachers. The scientific potential of the teaching staff exceeds 33%, which is a good indicator among faculties of medical institutes in the republic. Students from the Faculty of Dentistry actively participate in various practical conferences with their own scientific articles. They have managed to win the State Scholarships named after Abu Ali ibn Sina, Islam Karimov, Scholarship of the President of the Republic of Uzbekistan and the Scholarship of the regional governor. Talented students have been successfully participating in Olympiads held in the republic and abroad, winning honorable places.

By order of the rector of Andijan State Medical Institute No. 257-T dated August 25, 2022, by the decision of the supervisory board of the institute, the Faculty of Pharmacy was included in the current structure, and the directions of Pharmacy and Industrial Pharmacy were attached to this faculty. Currently, a Dean, three Deputy Deans, and a Methodologist actively work at the faculty. There are 13 departments functioning within the faculty, where 159 professors and teachers impart medical science knowledge to students. The number of students studying at the Faculty of Pharmacy is as follows: first-year students - 131, second-year students - 127, third-year students - 151, fourth-year students - 125, fifth-year students - 232, totaling 766 students altogether. Students from the faculty regularly participate in numerous Republican and International competitions. In particular, a fifth-year student Khakimova Oygul Sobitali kizi became the winner of the Republic competition "Woman of the Year" and also won the nomination "Promising Innovator" at "InnoWeek.uz-2023."